Production and Characterization of Colon Targeted pH Sensitive Macrospheres and Investigation of Release Kinetics

The gastrointestinal track has different pH values at sections. Thus, it is not easy to carry a drug the colon for absorption. sensitive polymeric macrosphere carriers have important advantages such as being able be taken orally, targeting active ingredient desired area and dosing concentration long time in target area. In this contex sodium alginate-gelatin macrospheres were produced by dispersion phase gelling cross-linking (complex coacervation) process method then loaded with Sternbergia lutea extract study. release kinetics investigated medias that simulates sections of track. As result, carrier released (pH 7.0) while lower did show significant release. Therefore, was reported potential used diseases treatments.